Nuclear receptors in renal health and disease

29 de March, 2022 by Susana Ferreira0
BiliaryTractCancer.png

Nuclear receptors in renal health and disease

As a major social and economic burden for the healthcare system, kidney diseases contribute to the constant increase of worldwide deaths. A deeper understanding of the underlying mechanisms governing the etiology, development and progression of kidney diseases may help to identify potential therapeutic targets. As a superfamily of ligand-dependent transcription factors, nuclear receptors (NRs) are critical for the maintenance of normal renal function and their dysfunction is associated with a variety of kidney diseases. Increasing evidence suggests that ligands for NRs protect patients from renal ischemia/reperfusion (I/R) injury, drug-induced acute kidney injury (AKI), diabetic nephropathy (DN), renal fibrosis and kidney cancers. In the past decade, some breakthroughs have been made for the translation of NR ligands into clinical use. This review summarizes the current understanding of several important NRs in renal physiology and pathophysiology and discusses recent findings and applications of NR ligands in the management of kidney diseases.

 Zhi-Lin Luan, Cong Zhang, Wen-Hua Min, Ying-Zhi Huang, You-Fei Guan, Xiao-Yan Zhang

© 2022 The Authors. Published by Elsevier B.V.


Leave a Reply

Your email address will not be published. Required fields are marked *



New Breathe

WE CARE, WE CAN





New Breathe

WE CARE, WE CAN




0-800-777-2331


24/7 EMERGENCY NUMBER

Call us now if you are in a medical emergency need, we will reply swiftly and provide you with a medical aid.




2021 © New Breathe. Powered with by Goweb Agency.



2021 © New Breath. Powered with by Goweb Agency.