The skin is our biggest organ and its cells renew in a regular and controlled way. Every day, skin cells age and die and are replaced by new cells. Sometimes this systematic process goes wrong, with new cells forming without the skin needing them, and without aging cells dying when they should. This excess of cells can form a mass of tissue called a neoplasm or tumor.
Scientific studies have shown that the most important external factor in the development of skin cancer is chronic and/or intermittent exposure to ultraviolet radiation from solar radiation or sunbeds.
The two most common types of nonmelanoma skin cancer are basal cell carcinoma and squamous cell carcinoma. This type of carcinoma represents, together, about 90% of all skin neoplasms and tend to appear on the head, face, neck, hands and arms, the areas most exposed to the sun. However, skin cancer can appear anywhere on the body.
Melanoma is a type of skin cancer that originates in pigment-producing skin cells called melanocytes. These cells transform and start to grow uncontrollably and invade the surrounding tissues. This type, although less common, is the most serious and represents about 10% of all cases. Furthermore, it is responsible for more than 2/3 of deaths from skin cancer, essentially when diagnosed late.
In the last 20 years, its incidence has increased substantially, with an estimated global mortality rate from melanoma at 5 years of age at around 15%. It is rarer in children and adolescents, but its incidence in the population under 20 years of age has increased, as well as in the general population.
As for treatment and diagnosis, self-examination and medical observation are good screening measures for early diagnosis. Most skin cancers are curable as long as they are diagnosed early. Surgical treatment of basal cell carcinoma and squamous cell carcinoma is usually curative.
In more advanced cases, squamous cell carcinoma may develop metastases, requiring oncological medical treatment. Melanoma, too, if treated surgically at a very early stage, is usually curable. However, there are currently several new oncologic medical therapies that have shown very promising results in the treatment of advanced melanomas.
Status | Study | Conditions | Interventions | Locations |
Recruiting | Patient Reported Outcome Measures After Treatment of Skin Cancers on the Face | Skin Cancer | Other: data collection by questionnaires
Other: data collection (photos of the patients’ tumors) |
Department of Plastic, Reconstructive and Aesthetic Surgery and Department of Dermatology , University Hospital Basel Basel, Switzerland |
Recruiting | SpotCheck: Comparison of Enhanced Telemedicine Versus In-person Evaluation for the Diagnosis of Skin Cancer | Skin Cancer | Device: Nevisense 3.0 Device: Dermlite Cam Procedure: Skin biopsy |
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Unknown | Transient Infrared Imaging for Early Detection of Skin Cancer | Skin Cancer |
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Recruiting | Photodynamic Therapy for Prevention of Nonmelanoma Skin Cancer in Organ Transplant Recipients | Nonmelanoma Skin Cancers | Other: have Levulan Kerastick (aminolevulinic acid) solution | Inova Melanoma Na Skin Oncology Center Fairfax, Virginia, United States |
Recruiting | Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer | Non-melanoma Skin Cancer | Drug: Solaraze and Vaniqa | UAB Dermatology Birmingham, Alabama, United States; University of Alabama at Birmingham Whitaker Clinic Birmingham, Alabama, United States |
Recruiting | A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin Cancer | Non-melanoma Skin Cancer |
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UAB Dermatology Birmingham, Alabama, United States |
Unknown | Electronic Brachytherapy (eBx)-Mohs Matched Pair – Cohort Study A Multi-Center Retrospective-Prospective Matched Pairs Cohort Study to Assess Long-term Clinical Outcomes of Non-melanoma Skin Cancer Patients Treated With eBx Compared to Non-melanoma Skin Cancer Patients Treated With Mohs Surgery | Nonmelanoma Skin Cancer | Kenneth A. Miller, PC Los Gatos, California, United States; Dermatology & Laser Center of San Diego San Diego, California, United States; Dermatology and Laser Center of San Diego San Diego, California, United States; Strimling Laser and Vein Institute Las Vegas, Nevada, United States |
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Suspended | Optical Frequency Domain Imaging for Non-melanoma Skin Cancers | Non-Melanoma Skin Cancer (NMSC) | Device: OFDI |
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Recruiting | Improving Skin Cancer Management With Artificial Intelligence (04.17 SMARTI) | Skin Cancer
Melanoma (Skin) |
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Recruiting | Comparative Retrospective Analysis of Skin Tumors of the Eyelids and Face in 2 Brussels University Hospitals Over 5 Years in Dermatology or Ophthalmology | Skin Cancer |
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